Author's response to reviews Title: Molecular, cellular and physiological characterization of the cancer cachexia-inducing C26 colon carcinoma in mouse Authors:

Aliskiren targets multiple systems to alleviate cancer cachexia.

To examine the effects of aliskiren, a small-molecule renin inhibitor, on cancer cachexia and to explore the underlying mechanisms. A cancer cachexia model was established by subcutaneously injecting C26 mouse colon carcinoma cells into isogenic BALB/c mice. Aliskiren was administered intragastrically [10 mg/kg body weight (BW)] on day 5 (as a preventive strategy, AP group) or on day 12 (as a t...

Physical Activity Counteracts Tumor Cell Growth in Colon Carcinoma C26-Injected Muscles: An Interim Report

Skeletal muscle tissue is a rare site of tumor metastasis but is the main target of the degenerative processes occurring in cancer-associated cachexia syndrome. Beneficial effects of physical activity in counteracting cancer-related muscle wasting have been described in the last decades. Recently it has been shown that, in tumor xeno-transplanted mouse models, physical activity is able to direc...

Author's response to reviews Title: Argonaute proteins: potential biomarkers for human colon cancer Authors:

Continuous Release of Tumor-Derived Factors Improves the Modeling of Cachexia in Muscle Cell Culture

Cachexia is strongly associated with a poor prognosis in cancer patients but the biological trigger is unknown and therefore no therapeutics exist. The loss of skeletal muscle is the most deleterious aspect of cachexia and it appears to depend on secretions from tumor cells. Models for studying wasting in cell culture consist of experiments where skeletal muscle cells are incubated with medium ...

Author's response to reviews Title: Fucoidan present in brown algae induces apoptosis of HT-29 human colon cancer cells Authors:

Title: Fucoidan present in brown algae induces apoptosis of HT-29 human colon cancer cells